Beckman Coulter
Multisizer 4e

Coulter Coulter – Particle Size and Count Analyser

  • Unparalleled sizing range of 0.2 – 1600 μm
  • Advanced noise reduction system
  • Patented digital pulse processing technology

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The Multisizer 4e provides accurate particle and cell counting. It is the most accurate and flexible particle characterization device available, boasting an unparalleled sizing range of 0.2 – 1600 μm. The new 10 μm Aperture allows users to study sub-cellular and micro-particles as small as 200 nm, while the advanced noise reduction system for small apertures improves measurement accuracy.

Accurate particle and cell counting

The Multisizer 4e Coulter Counter is used in a number of diffrernt fields for counting and sizing both particles and call. Applications include: Quality Control, Research and Development, Pharmaceutical Analysis, Biotechnology Applications and Industrial Applications.

  • Key Features

    Versatility
    • Aperture sizes from 10 µm – 2000 µm in diameter for current & future needs
    • Multiple aperture options & data overlay capability for analyzing complex samples over wide particle size distribution
    Sample Detection
    • Analyse materials in aqueous or non-aqueous solvents
    • Ideal for biological or non-biological samples
    • Detect particles regardless of material type or optical properties
    Rapid Particle Counting
    • Typical sampling rates up to 10,000 counts per second
    • Detect & count particles from 0.2 µm – 1600 µm in diameter
    • Sample volumes as small as 5 mL
    Data Management
    • Digital pulse data can be stored & re-analysed as needed
    • CFR 21 Part 11 compliant software for audit control & security
    • Variety of calibration beads & V-check validation controls

  • Technical Specs

    Particle Sizing Range

    Diameter: 0.2 – 1,600 µm
    Volume: 0.004 – 2.145 x 109 µm3
    Aperture Size

    10 – 2,000 µm (nominal diameter)
    Measurement range

    Extended: 2 – 80% of aperture size
    Standard: 2 – 60% aperture size
    Measurement linearity

    Diameter: ± 1%
    Volume: ± 3%
    Dynamic range (accuracy)

    Diameter: 1 : 40 (extended), 1 :30 (standard),
    Volume: 1 : 64,000 (extended), 1: 27,000 (standard)
    Processor type

    High speed signal digitalisation
    Number of pulses measured

    Up to 525,000 per analysis
    Resolution

    User difined
    Number of size classes

    Up to 400 for display of any selected measurement range
    The number of classes and their width can be changed as needed
    Pulse distribution data

    X axis: time, registration sequence, pulse width
    Y axis: diameter, volume or voltage corresopnding to pulse amplitude,
    pulse width, mean diameter, volume, or voltage corresponding to pulse
    amplitude, average pulse width, pulse distribution by width
    Particle size distribution data

    X axis: diameter, volume, surface area
    Y axis: absolute number, percent content (%), number per ml, absolute volume, volume percentage (%) volume per ml, absolute surface area (%) surface area per ml
    Sample registration mode:
    total number of particles

    50 – 500,000 counts
    Sample registration mode:
    number of particles and
    measurement of parameters

    10 – 100,000 counts
    Sample registration mode:
    time

    0.1 – 999 seconds with 10 ms increments
    Standard registration time is 10 – 90 seconds
    Sample registration mode:
    volume

    50 – 2,000 µL
    Dosage system

    The dosing pump with even suspension flow across the aperture and volume measurement, error – less than 0.5%
    Electrolyte type:

    Aqueous and non-aqueous electrolyte solutions compatible with glass, fluoropolymers, fluoroelastomers and stainless steel
    Aperture current strength range:

    30 – 6,000 µA with 0.2µA increments
    Aperture current stability:

    ± 0.4% of set value
    Polarity error

    Less than 0.5%
    Compliance with standards

    Software is 21 CFR part 11 compliant
    Dimensions

    64 x 61 x 51 cm, weight 45 kg
    Power supply requirements

    230 – 240 V ± 10%, 47 – 63 Hz
    Power consumption

    Less than 55 Watts
    Fuses

    250 V, IEC (5×20 mm) with time delay, 2.0 A
    Environmental requirements

    The instrument is intended for work in enclosed spaces
    Working temperature: 5 – 40°C
    Relative humidity: 30 – 85% without condensation

  • Applications

    Yeast

    Beer

    Protein

    E. coli

    Plant Cells

    CAR-T Cells

  • Capabilities

    The Multisizer 4e particle sizer and counter is the most accurate and flexible particle characterization device available, boasting an unparalleled sizing range of 0.2 – 1600 μm. The new 10 μm Aperture allows users to study sub-cellular and micro-particles as small as 200 nm, while the advanced noise reduction system for small apertures improves measurement accuracy.

    Generated data are processed using patented digital pulse processing technology and can be saved and later re-analyzed. This technology provides ultra high resolution and accuracy unattainable through any other technologies: detection of 1 particle in 1 ml of a sample with the optimal instrument configuration. Analysis results are not dependent on particle shape, structure, or optical properties.

    It uses the Coulter principle to detect particles via electrical zone sensing, regardless of the particle’s nature or optical properties. This makes it an ideal tool for detecting and counting a wide variety of particles, such as:

    • Mammalian cells
    • Bacteria
    • Yeast
    • Abrasives
    • Toner particles
    • Cell aggregates
    • Spheroids
    • Large protein aggregates


    More information from
    Beckman Coulter

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  • Outstanding service

    I have been using Meritics for a number of years and they always provide outstanding service and support.
    They have a rapid response turnarounds and are very knowledgeable of the techniques and products they provide.

    LeanneB-375

  • Good service, very helpful

    We use Meritics for the PM service and installation of all our FlowCams . Megan has been coming to our site for a number of years. She is very efficient in her work, but most of all Megan is very helpful. We have had issues with one of instruments after the install and Megan did her utmost to try and solve it while on site, even though it wasn’t solved Megan has been in contact with the supplier of the instrument to try and solve this problem for us.

    SophieH-2201

  • Job done in a friendly manner

    Booking engineer visits is always easy. David Lowe, Meritics engineer is always very friendly.

    ThierryN

  • Service/calibration visit

    Excellent service, arrived on time, polite, friendly and informative.

    NathamM-270

  • 5 Stars

    Excellent service from an excellent company. Would recommend them to anyone.

    BarryH-480

  • Good Service

    David, our service engineer as usual was good at communicating and setting up the recent service appointment, he arrived on time, did the service promptly and informed me of any problems. Friendly and helpful

    TomA-446

  • Superb and prompt service

    I have used this company through the laboratory I work for frequently. We specialise in soil analysis, and Meritics were chosen as they have extensive knowledge of the instruments we use. We have several laser particle diffraction analysers with a service contract, and service is always very prompt and meticulous….

    JamesG-2483

  • Good experience over two years

    Meritics have covered the annual servicing of our Multisizer 4e instrument since we purchased it from them just over two years ago. The application scientist who performed the servicing was friendly, knowledgeable, and extremely helpful, happily answering a barrage of questions about how best to use and maintain the instrument. All my interactions with Meritics staff have been positive. I would happily recommend them.

    RajG-62

  • Fully committed to customer service

    Service second to none, both units serviced and all questions answers by engineer while on site.

    RichardA-786

  • Highly recommend Meritics for equipment purchases and aftercare services

    After owning one of our instruments for over 8 Years which was purchased from Meritics, it suffered its first breakdown. Upon contacting Meritics, I was instantly put through to an engineer who was very helpful. Upon inspection of the manual, it was decided that it would be more cost effective to have a Meritics engineer visit. The Meritics staff were very communicative and kept me up to date.

  • Excellent Service

    Lovely, friendly and extremely helpful. David and his team are always on call with advise and are very easy to work with and are always happy to help.

    NaomiT-64

  • Service of lab equipment

    Excellent service. Friendly and professional service was provided in a timely manner to the expected standard.

    NathanM-270

  • Excellent

    Excellent communication. Updates given well in advance. Very polite staff and engineers.

    NathanM-270

  • Multisizer 4e install at pharmaceutical company

    2 people helped with the install of a Multisizer 4e. They were both very professional and friendly, answering any questions that I had. The installation was quick and the attention to good documentation practice was exceptional.

    Chloel-9

  • Service of Beckman Coulter instruments

    Always a pleasure to welcome the Meritics service engineer, who is knowledgeable, personable and extremely competent.

    NeilT-394

  • Professional

    Friendly and collaborative staff, provided a very good service.

    SamK-403

  • Professional, Customer-oriented, fast service

    We had issues with one of the aperture tubes provided by Meritics on a Friday afternoon, while very pressed for a review deadline. Meritics handled our inquiries very fast and professionally and helped us out by shipping us their spare tube to use in the mean time free of charge, while we waited for our new tube to arrive. Communication was very pleasant.

    VeerleB

  • Very helpful and prompt

    I emailed for some technical help and also to get some spares and both the engineer (David) and purchasing (Sophie) were very prompt to respond and helpful. We do have a service contract but I appreciated being able to email the engineer directly.

    AlexH-474

  • Excellent Service

    Used Meritics to conduct particle size distribution by laser diffraction. Service as last time, is very quick, well priced and professional.

    I would highly recommend

    GavinR-101

  • Excellent and Friendly Service

    Always a pleasure to deal with the people at Meritics Ltd. They understand the importance of our work and the fact that our research projects have deadlines that need to be met. Consequently, problems are dealt with very quickly and professionally and they are willing to go that one step further to make sure their supply chain problems don’t become our problems. Thank you to the team for their support. It is greatly appreciated.

    JanetH-255