Biological Information
Gene and Cell Therapy

Why particle characterisation is important in Gene and Cell Therapy

Characterisation is crucial for ensuring safety, efficacy, and consistency. It helps identify the genetic modifications, monitor cell health, and assess therapeutic potential. Precise characterisation ensures regulatory compliance, guides treatment development, and optimises patient outcomes by tailoring therapies to individual genetic profiles.

Cell Size

Cell size is crucial in gene and cell therapy as it influences cellular uptake, viability, and therapeutic efficacy. Accurate size measurement ensures optimal cell selection and enhances treatment outcomes.

Cell Counting

Cell counting is vital for ensuring accurate dosing, monitoring therapeutic progress, and maintaining quality control. Precise counts ensure treatment consistency and regulatory compliance.

Surface Plasmon Resonance

Surface plasmon resonance is crucial in gene and cell therapy for analyzing biomolecular interactions in real-time, aiding in the identification of binding affinities, kinetics, and specificity, thus enhancing therapeutic development and efficacy.

Case study

In gene regulation studies, understanding molecular interactions between DNA, RNA, proteins, and small molecules is critical. The P4SPR (Four-Channel Surface Plasmon Resonance) system proves invaluable in analyzing these interactions in real-time, offering precise data on binding kinetics and affinities. The objective was to utilise the P4SPR system to study the binding dynamics between transcription factors and regulatory DNA sequences, crucial for elucidating gene expression mechanisms.

The P4SPR system is a powerful tool for studying gene regulation by providing real-time insights into molecular interactions. Its ability to quantify binding affinities and kinetics aids in deciphering complex regulatory networks and designing targeted interventions in gene therapy and biotechnology. This case study underscores the P4SPR’s role in advancing our understanding of gene regulation mechanisms, offering potential applications in therapeutic development and personalized medicine.

Instruments to support Gene & Cell Therapy

Applications to support Gene & Cell Therapy

Extracellular Vesicles and Exosomes Applications Note

Liposomes and Lipid Nanoparticles Application Note

nCS2 Gene Therapy Application Note

Exosomes Application Note

Extracellular Vesicles Application Note

Gene Regulation Application Note

CAR-T Cell Therapy

Fat Emulsion Application Note

Rapid Apoptosis Monitoring Application Note

Transfection Efficiency Monitoring Application Note

PBMC-Immunophenotyping Application Note

Mitochondrial Membrane Potential Application Note

Reactive Oxygen Species Application Note

Blood Cell Application Note

Monitoring Cell Culture Health Application Note