Yokogawa Fluid Imaging Technologies
FlowCam LO

Flow Imaging Microscopy with Light Obscuration

  • Measurement range 2 µm to 70 µm
  • FIM and LO to fulfill USP <787> and <788>
  • Quality control of subvisible particulate matter

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Beckman Coulter LS 13 320 XR Laser Diffraction Particle Size Analyser 21 CFR Part 11

FlowCam LO

Innovative particle characterisation with FlowCam LO combines flow imaging microscopy (FIM) and light obscuration (LO) into a single analytical solution.

Beyond the compendial light obscuration method to fulfill USP <787> and <788> requirements, flow imaging microscopy provides an orthogonal method for quality control of subvisible particulate matter.

  • Overview

    USP <1788> introduces flow imaging as a technique to provide complementary morphology information and to overcome undercounting and undersizing challenges with the light obscuration method when measuring translucent particles such as proteins and other biological drugs.

    Obtain light obscuration data to meet USP regulatory guidelines and verify your results with the highest quality images in FlowCam LO – all in a single instrument and single sample run.

  • Technical Specs

    Size Range

    2 µm to 70 µm; Flow imaging module: 10x (~100x magnification)

    Solvent compatibility:

    Wide range of aqueous and organic fluids, including high-viscosity solvents and buffers

    Minimum sample Volume

    100 μL

    Sample flow rate

    0.2 mL/minute

    Camera type

    High resolution (1920 x 1200 pixels) CMOS, monochrome

    Software

    Ease of use instrumentation & fully integrated VisualSpreadsheet software with optional VisualAI software module

  • Benefits

    • Perform both flow imaging and light obscuration measurements sequentially in the same instrument
    • Obtain compendial particle sizing and counting according to USP <787> and <788>
    • Acquire statistically significant results in less than a minute, with as little as 100 μL of sample
    • Monitor and control particulates in your formulations
  • Applications

    Protein Therapeutics

    Other Therapeutics

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  • Outstanding service

    I have been using Meritics for a number of years and they always provide outstanding service and support.
    They have a rapid response turnarounds and are very knowledgeable of the techniques and products they provide.

    LeanneB-375

  • Good service, very helpful

    We use Meritics for the PM service and installation of all our FlowCams . Megan has been coming to our site for a number of years. She is very efficient in her work, but most of all Megan is very helpful. We have had issues with one of instruments after the install and Megan did her utmost to try and solve it while on site, even though it wasn’t solved Megan has been in contact with the supplier of the instrument to try and solve this problem for us.

    SophieH-2201

  • Job done in a friendly manner

    Booking engineer visits is always easy. David Lowe, Meritics engineer is always very friendly.

    ThierryN

  • Service/calibration visit

    Excellent service, arrived on time, polite, friendly and informative.

    NathamM-270

  • 5 Stars

    Excellent service from an excellent company. Would recommend them to anyone.

    BarryH-480

  • Good Service

    David, our service engineer as usual was good at communicating and setting up the recent service appointment, he arrived on time, did the service promptly and informed me of any problems. Friendly and helpful

    TomA-446

  • Superb and prompt service

    I have used this company through the laboratory I work for frequently. We specialise in soil analysis, and Meritics were chosen as they have extensive knowledge of the instruments we use. We have several laser particle diffraction analysers with a service contract, and service is always very prompt and meticulous….

    JamesG-2483

  • Good experience over two years

    Meritics have covered the annual servicing of our Multisizer 4e instrument since we purchased it from them just over two years ago. The application scientist who performed the servicing was friendly, knowledgeable, and extremely helpful, happily answering a barrage of questions about how best to use and maintain the instrument. All my interactions with Meritics staff have been positive. I would happily recommend them.

    RajG-62

  • Fully committed to customer service

    Service second to none, both units serviced and all questions answers by engineer while on site.

    RichardA-786

  • Highly recommend Meritics for equipment purchases and aftercare services

    After owning one of our instruments for over 8 Years which was purchased from Meritics, it suffered its first breakdown. Upon contacting Meritics, I was instantly put through to an engineer who was very helpful. Upon inspection of the manual, it was decided that it would be more cost effective to have a Meritics engineer visit. The Meritics staff were very communicative and kept me up to date.

  • Excellent Service

    Lovely, friendly and extremely helpful. David and his team are always on call with advise and are very easy to work with and are always happy to help.

    NaomiT-64

  • Service of lab equipment

    Excellent service. Friendly and professional service was provided in a timely manner to the expected standard.

    NathanM-270

  • Excellent

    Excellent communication. Updates given well in advance. Very polite staff and engineers.

    NathanM-270

  • Multisizer 4e install at pharmaceutical company

    2 people helped with the install of a Multisizer 4e. They were both very professional and friendly, answering any questions that I had. The installation was quick and the attention to good documentation practice was exceptional.

    Chloel-9

  • Service of Beckman Coulter instruments

    Always a pleasure to welcome the Meritics service engineer, who is knowledgeable, personable and extremely competent.

    NeilT-394

  • Professional

    Friendly and collaborative staff, provided a very good service.

    SamK-403

  • Professional, Customer-oriented, fast service

    We had issues with one of the aperture tubes provided by Meritics on a Friday afternoon, while very pressed for a review deadline. Meritics handled our inquiries very fast and professionally and helped us out by shipping us their spare tube to use in the mean time free of charge, while we waited for our new tube to arrive. Communication was very pleasant.

    VeerleB

  • Very helpful and prompt

    I emailed for some technical help and also to get some spares and both the engineer (David) and purchasing (Sophie) were very prompt to respond and helpful. We do have a service contract but I appreciated being able to email the engineer directly.

    AlexH-474

  • Excellent Service

    Used Meritics to conduct particle size distribution by laser diffraction. Service as last time, is very quick, well priced and professional.

    I would highly recommend

    GavinR-101

  • Excellent and Friendly Service

    Always a pleasure to deal with the people at Meritics Ltd. They understand the importance of our work and the fact that our research projects have deadlines that need to be met. Consequently, problems are dealt with very quickly and professionally and they are willing to go that one step further to make sure their supply chain problems don’t become our problems. Thank you to the team for their support. It is greatly appreciated.

    JanetH-255