Beckman Coulter
BioLector XT

Microbioreactor

  • Multiple processe
  • Enhanced PIDS Technology
  • Real data down to 10nm

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Beckman Coulter LS 13 320 XR Laser Diffraction Particle Size Analyser 21 CFR Part 11

BioLector XT microbioreactor accelerates your bioprocess development

High-throughput microbioreactor enables real-time evaluation of biomass, fluorescence, pH, dissolved oxygen in the liquid phase (DO), and other key cultivation parameters for aerobes and anaerobes. Building on trusted BioLector Pro technology, the BioLector XT microbioreactor is based on a standard ANSI/SLAS (SBS) microtiter plate (MTP) format, and operates with online, pre-calibrated optical sensors. Disposable 48 well MTPs enable online measurement of cultivation parameters, while patented microfluidic technology supports simultaneous pH control and feeding. The optional microfluidic module eliminates manual liquid handling—no tubing or pipetting required, as everything is part of the beta-radiated ready-to-use plate.

Meritics are proud to partner with Beckman Coulter Life Sciences by hosting the UK demonstration unit of the BioLector XT microbioreactor at our premises. Extensive experience within the UK biologics sector and highly rated application and laboratory personnel makes Meritics the ideal partner to showcase the BioLector XT microbioreactor and its real-world applications.

© 2023 Beckman Coulter, Inc. All rights reserved. Beckman Coulter, the stylized logo and the Beckman Coulter product and service marks mentioned herein are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries. All other trademarks are the property of their respective owners.

  • Key Features

    Innovative New Gassing Head
    • Enables fed-batch experiments under anaerobic conditions
    • Gassing with O2 within a range of 1% – 100% and with CO2 within 1% – 12 %
    • Reduces gas consumption to a few mL/minute
    • Optional humidification of gases reduces evaporation
    Optional Microfluidic Module
    • Unleashes full potential of the BioLector XT
    • Complements online monitoring function with well-specific pH regulation/feeding
    • Enables use of 2 reservoir wells per 4 cultivation wells
    • Microvalves allot liquids at nanoliter-scale
    “Plug-and-play” Plate Design
    • Real-time kinetics out of 48/32 parallel cultivations
    • Customisable feeding strategies (batch, fed-batch, bolus, continuous)*
    • Control of pH on-the-plate with pre-calibrated optical sensors*
    • Small working volume (800 – 2400 μL)

    *Functionality requires optional microfluidic module

    Intelligent BioLection Software
    • Intuitive user interface supports multi-user environments
    • Free programming of all control parameters
    • Open system enables live data downloads
    • Fast processor ensures rapid download of experiment data

  • Technical Specs

    Volume

    800 – 2400 µL
    pH Range

    pH 4 – 7.5 (depending on plate)
    Scattered Light Measurement

    Resolution > 50 NTU, at densities higher than 500 NTU: 10 % of measured value.
    Height

    522 mm(20.6 in)
    Width

    797 mm(31.4 in)
    Depth

    520 mm(20.5 in)
    Temperature range

    10 – 50 °C (minimum temperature 8 °C below ambient temperature)
    DO Range

    0 – 100% oxygen saturation (100% corresponding to the DO level reached while gassing with 100% O2 without O2 consumption)
    Wavelengths

    365 nm–800 nm
    Weight

    61 kg(134.5 lb)

  • Accessories

    Microfluidic Module

    The microfluidic (MF) module for the BioLector XT microbioreactor allows you to run up to 32 highly flexible, pH-controlled fed-batch cultivations in microscale during one cultivation experiment run.

    Anaerobic Clutivation

    The anaerobic module for the BioLector XT microbioreactor enables strict anaerobic fermentation processes combined with a controlled, low nitrogen gas flow rate.

    CO2 Up Regulation

    With the CO2 up-regulation module the microbioreactor continuously measures the CO2 level inside the chamber and automatically regulates the flow of CO2 into the chamber.

    LED Filter

    With the LED / filter module, the microbioreactor can measure additional fluorescences. An LED unit and two optical filter glasses are installed inside the BioLector microbioreactor.

    O2 Down Regulation

    With the O2 down-regulation module the microbioreactor continuously measures the oxygen level inside the chamber and automatically regulates the flow of nitrogen into the chamber.

    O2 Up Regulation

    With the O2 up-regulation module the microbioreactor continuously measures the oxygen level inside the chamber and automatically regulates the flow of oxygen into the chamber.

    There is more information on all the accessories on the Beckman Coulter website

  • Applications

    Yeast

    E. coli

    Probiotic Bacteria

    Plant Cells

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    We use Meritics for the PM service and installation of all our FlowCams . Megan has been coming to our site for a number of years. She is very efficient in her work, but most of all Megan is very helpful. We have had issues with one of instruments after the install and Megan did her utmost to try and solve it while on site, even though it wasn’t solved Megan has been in contact with the supplier of the instrument to try and solve this problem for us.

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    Meritics have covered the annual servicing of our Multisizer 4e instrument since we purchased it from them just over two years ago. The application scientist who performed the servicing was friendly, knowledgeable, and extremely helpful, happily answering a barrage of questions about how best to use and maintain the instrument. All my interactions with Meritics staff have been positive. I would happily recommend them.

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  • Highly recommend Meritics for equipment purchases and aftercare services

    After owning one of our instruments for over 8 Years which was purchased from Meritics, it suffered its first breakdown. Upon contacting Meritics, I was instantly put through to an engineer who was very helpful. Upon inspection of the manual, it was decided that it would be more cost effective to have a Meritics engineer visit. The Meritics staff were very communicative and kept me up to date.

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    Used Meritics to conduct particle size distribution by laser diffraction. Service as last time, is very quick, well priced and professional.

    I would highly recommend

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    Always a pleasure to deal with the people at Meritics Ltd. They understand the importance of our work and the fact that our research projects have deadlines that need to be met. Consequently, problems are dealt with very quickly and professionally and they are willing to go that one step further to make sure their supply chain problems don’t become our problems. Thank you to the team for their support. It is greatly appreciated.

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