Exosomes? Virus? Nanoparticle? Use multiple lasers for complete, detailed analysis of all the particles in your sample.
Exosomes, viruses, and nanoparticles all have wide size distributions which defeat traditional Nanoparticle Tracking Analysis (NTA) analyzers. The ViewSizer 3000 features simultaneous measurement with three lasers to collect the most accurate distribution and concentration information over a wide range of sizes within the same sample. Where the signal from a particle is too bright and saturates the detector from one laser, the software automatically uses data from a lower power laser to ensure the most accurate size and concentration information. On the other hand, when scattering from one laser is too weak for detection, the software uses data from a higher power laser to accurately track the particle.
Cross contamination is a concern in all analyses. Simplified cleaning means thorough cleaning. The easy-to-remove sample cells can be dissassembled for rapid, thorough cleaning, which leads to better data.
Escape the limits of traditional Nanoparticle Tracking Analysis
Accurate and sensitive analysis without cross contamination
Biological characterization using protein crystal measurements | https://bioprocessintl.com/analytical/product-characterization/biological-characterization-using-protein-crystal-measurements/ |
A lipase-independent pathway of lipid release and immune modulation by adipocytes | https://science.sciencemag.org/content/363/6430/989 |
Application of a novel new multispectral nanoparticle tracking technique | https://iopscience.iop.org/article/10.1088/1361-6501/aab940/meta |
Biophysical characterization of polydisperse liposomal adjuvant formulations | https://doi.org/10.1016/j.bbrc.2020.05.156 |
Characterisation of particles in solution – a perspective on light scattering and comparative technologies | https://doi.org/10.1080/14686996.2018.1517587 |
Cyclodextrin Reduces Intravenous Toxicity of a Model Compound | https://doi.org/10.1016/j.xphs.2019.01.004 |
Development and anti-Candida evaluation of the vaginal delivery system of … nanosuspension-loaded thermogel | https://doi.org/10.1080/1061186X.2018.1434660 |
Electrochemical sensor based on F,N-doped carbon dots decorated laccase for detection of catechol | https://doi.org/10.1016/j.jelechem.2019.03.071 |
Light scattering by pure water and seawater: the depolarization ratio and its variation with salinity | https://doi.org/10.1364/AO.58.000991 |
Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis | https://doi.org/10.1016/j.ymthe.2018.05.014 |
Mesenchymal Stromal Cell Bioreactor for Ex Vivo Reprogramming of Human Immune Cells | https://doi.org/10.1038/s41598-020-67039-w |
Multifunctional Nanocomposites Based on Liposomes and Layered Double Hydroxides Conjugated with Glycylsarcosine for Efficient Topical Drug Delivery to the Posterior Segment of the Eye | https://doi.org/10.1021/acs.molpharmaceut.8b01136 |
Particle size analysis of polydisperse liposome formulations with a novel multispectral advanced nanoparticle tracking technology | https://doi.org/10.1016/j.ijpharm.2019.06.013 |
Review of nanoparticles in ultrapure water: definitions and current metrologies for detection and control | https://www.ovivowater.com/review-of-nanoparticles-in-ultrapure-water-definitions-and-current-metrologies-for-detection-and-control/ |
Spark erosion as a high-throughput method for producing bimodal nanostructured 316L stainless steel powder | https://doi.org/10.1016/j.powtec.2018.01.012 |
Synthesis and Characterization of EGFR-Targeted Immunoporphysomes | http://hdl.handle.net/1807/89548 |
Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions | https://pubs.acs.org/doi/abs/10.1021/acsabm.9b00747 |
Nanoparticle Tracking Analysis for the Quantification and Size Determination of Extracellular Vesicles | Protocol (jove.com) | https://doi.org/10.3791/62447 |
Isolation and characterization of EV in Saliva of Children with Asthma | https://evcna.com/article/view/3962 |
Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potential | https://doi.org/10.1016/j.bbi.2020.12.007 |
Skeletal muscle tissue secretes more extracellular vesicles than white adipose tissue and myofibers are a major source ex vivo but not in vivo | https://doi.org/10.1101/2020.09.27.313932 |
Human milk extracellular vesicle miRNA expression and associations with maternal characteristics in a population-based cohort from the Faroe Islands | https://www.nature.com/articles/s41598-021-84809-2 |
Purification of Cas9 – RNA Complexes by Ultrafiltration | https://doi.org/10.1002/btpr.3104 |
Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications | https://doi.org/10.1002/smtd.202100785 |
Bioactive extracellular vesicles from a subset of endothelial progenitor cells rescue retinal ischemia and neurodegeneration | https://doi.org/10.1172/jci.insight.155928 |
Circulating Extracellular Vesicles From Septic Mice Induce Brain Inflammation via Mirna Cargo | http://hdl.handle.net/10713/19055 |
Measurement Range
|
10 nm to 15 μm |
Typical Sample Volume
|
350 µL to 2.5 mL |
Typical Sample Concentration
(Sample dependent) |
10^5 – 10^9 particles/mL/p> |
Sample Temperature Range
(Controlled) |
10° C to 50° C +/- 0.1° C |
Dimensions
|
55 cm W x 66 cm D x 35 cm H |
Weight
|
27 kg |
Operational Environment
|
15° C to 30° C with < 85% RH |
I have been using Meritics for a number of years and they always provide outstanding service and support.
They have a rapid response turnarounds and are very knowledgeable of the techniques and products they provide.
LeanneB-375
We use Meritics for the PM service and installation of all our FlowCams . Megan has been coming to our site for a number of years. She is very efficient in her work, but most of all Megan is very helpful. We have had issues with one of instruments after the install and Megan did her utmost to try and solve it while on site, even though it wasn’t solved Megan has been in contact with the supplier of the instrument to try and solve this problem for us.
SophieH-2201
Booking engineer visits is always easy. David Lowe, Meritics engineer is always very friendly.
ThierryN
Excellent service, arrived on time, polite, friendly and informative.
NathamM-270
Excellent service from an excellent company. Would recommend them to anyone.
BarryH-480
David, our service engineer as usual was good at communicating and setting up the recent service appointment, he arrived on time, did the service promptly and informed me of any problems. Friendly and helpful
TomA-446
I have used this company through the laboratory I work for frequently. We specialise in soil analysis, and Meritics were chosen as they have extensive knowledge of the instruments we use. We have several laser particle diffraction analysers with a service contract, and service is always very prompt and meticulous….
JamesG-2483
Meritics have covered the annual servicing of our Multisizer 4e instrument since we purchased it from them just over two years ago. The application scientist who performed the servicing was friendly, knowledgeable, and extremely helpful, happily answering a barrage of questions about how best to use and maintain the instrument. All my interactions with Meritics staff have been positive. I would happily recommend them.
RajG-62
Service second to none, both units serviced and all questions answers by engineer while on site.
RichardA-786
After owning one of our instruments for over 8 Years which was purchased from Meritics, it suffered its first breakdown. Upon contacting Meritics, I was instantly put through to an engineer who was very helpful. Upon inspection of the manual, it was decided that it would be more cost effective to have a Meritics engineer visit. The Meritics staff were very communicative and kept me up to date.
Lovely, friendly and extremely helpful. David and his team are always on call with advise and are very easy to work with and are always happy to help.
NaomiT-64
Excellent service. Friendly and professional service was provided in a timely manner to the expected standard.
NathanM-270
Excellent communication. Updates given well in advance. Very polite staff and engineers.
NathanM-270
2 people helped with the install of a Multisizer 4e. They were both very professional and friendly, answering any questions that I had. The installation was quick and the attention to good documentation practice was exceptional.
Chloel-9
Always a pleasure to welcome the Meritics service engineer, who is knowledgeable, personable and extremely competent.
NeilT-394
Friendly and collaborative staff, provided a very good service.
SamK-403
We had issues with one of the aperture tubes provided by Meritics on a Friday afternoon, while very pressed for a review deadline. Meritics handled our inquiries very fast and professionally and helped us out by shipping us their spare tube to use in the mean time free of charge, while we waited for our new tube to arrive. Communication was very pleasant.
VeerleB
I emailed for some technical help and also to get some spares and both the engineer (David) and purchasing (Sophie) were very prompt to respond and helpful. We do have a service contract but I appreciated being able to email the engineer directly.
AlexH-474
Used Meritics to conduct particle size distribution by laser diffraction. Service as last time, is very quick, well priced and professional.
I would highly recommend
GavinR-101
Always a pleasure to deal with the people at Meritics Ltd. They understand the importance of our work and the fact that our research projects have deadlines that need to be met. Consequently, problems are dealt with very quickly and professionally and they are willing to go that one step further to make sure their supply chain problems don’t become our problems. Thank you to the team for their support. It is greatly appreciated.
JanetH-255